No one else was injured in the shootings just before 11 a.m. at Broward Community College.
The two died at Broward General Medical Center; their names were not immediately released. The woman, a student at the college just southwest of Fort Lauderdale, was the man's ex-girlfriend, police Maj. Edward Taylor said.
Several students witnessed the shootings, which happened near the performing arts building.
"I turned around and I saw the girl was shot," said Joe Fazio, a student from Plantation. "It looks like she was shot in the back of the neck. Then I heard the second gunshot. I turned around and the guy was laying on the ground."
It was the third shooting at a school in the past week.
On Wednesday, the dean, a professor and a student were shot and killed at Appalachian School of Law in Grundy, Va. A student who had recently flunked out was arrested.
Two students were shot and wounded Tuesday at Martin Luther King Jr. High School on New York City's Upper West Side. A teen-ager was arrested Friday.
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