The Alabama teen has been missing on the island more than two months.
Twitty says she wishes she could talk with Natalee: "She knows my message, that we are doing everything we possibly can, and we are determined to stay with this and to keep the pressure on."
But Twitty has set a tentative date to leave Aruba again, September 4th, the day suspect Joran van der Sloot could be released if authorities fail to make their case.
Twitty says, "The clock is also ticking for Natalee Holloway to be found and right now, I'm looking at … September 4th, and that's all I can think about right now."
The 17-year-old van der Sloot is the only suspect still being held in connection with Natalee's disappearance.
He continues to face daily interrogations, but his lawyer, Antonio Carlo, asserts he should ultimately be set free.
"Our client is maintaining his innocence and there is no basis to bring this matter to court," Carlo says.
Twitty says she also believes two Surinese brothers, who were detained and then released, but may still be suspects, know more than they're telling investigators.
The brothers, Deepak Kalpoe, 21, and Satish Kalpoe, 18, along with van der Sloot, were the last people seen in public with Natalee, 18, before she vanished in the early hours of May 30 on the final night of a high school graduation trip to the island.
But their attorneys say they're not ducking the truth.
Says David Kock, Satish Kalpoe's lawyer, "Nobody wants for the case to go away. …People want this case to be solved."
No one, Kirsch points out, more than Holloway's family.
Her uncle, Paul Reynolds, was adamant: "No there is no end. …We are cycling back and forth…jobs and families. …We're not going to leave.